Hyperthermia

Daniel Ortega received his MSc (2003) and PhD (2007) at the University of Cádiz supervised by Manuel Domínguez and Milagrosa Ramírez, undertaking his first postdoctoral position at the University of the Basque Country in 2008 working with José S. Garitaonandia and Fernando Plazaola. Starting in 2009, he joined The Royal Institution of Great Britain and University College London to work with Quentin Pankhurst, first as an Intraeuropean Marie Curie postdoctoral fellow and thereafter as a research associate. During this period he was awarded an honorary research associate position at the London Centre for Nanotechnology. He was appointed to the Toyohashi University of Technology in 2013 as research associate to Adarsh Sandhu’s lab. Since late 2013 he joined IMDEA Nanociencia through a Marie Curie action, also holding an honorary position at the UCL Institute of Biomedical Engineering. Daniel currently belongs to the CNB-IMDEA Nanociencia Associated Unit.

The group is focused in bespoke magnetic nanoparticles with applications in biomedicine. More specifically:

1. We work in the design and exploitation of magnetocaloric nanomaterials for distinct therapeutic and diagnostic applications: cardiovascular diseases, drug delivery, molecular detection, etc.
2. We are also interested in a wide range of other magnetic nanomaterials applied to biomedicine; for example, magnetic hyperthermia to treat localised cancers by heat genera- tion through hysteretic losses under AC fields.
3. We are developing a treatment planning software for clinical magnetic hyperthermia.

• In Vivo Early Tumor Detection and Diagnosis by Infrared Luminescence Transient Nanothermometry. Santos, H.D.A., Ximendes, E.C., Iglesias-de la Cruz, M.D.C., Chaves-Coira, I., del Rosal, B., Jacinto, C., Monge, L., Rubia-Rodríguez, I., Ortega, D., Mateos, S., García Solé, J., Jaque, D., Fernández, N. Advanced Functional Materials (2018)  Volume 28, Issue 43. 
• Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury. Riegler, J. et al,. Biomaterials (2013), 34, 1987-1994.
• Magnetic hyperthermia. Ortega, D.; Pankhurst, Q. A.. Nanoscience: Volume 1: Nanostructures through Chemistry. O'Brien, P., Ed. Royal Society of Chemistry: Cambridge (2012); Vol. 1, pp 60-88 (Book chapter). 
• Rapid magnetic cell delivery for large tubular bioengineered constructs. Gonzalez-Molina, J. et al,. J. R. Soc. Interface (2012) 6, 3008-3016.